The Mandovi River flows through Cumbarjua, Divadi and Chodné along the way. The waters of the Mandovi and Zuari both flush out into the Arabian Sea at a common point at Cabo Aguada forming the Marmogoa harbour. Panaji, the state capital and Old Goa, the former capital of Goa, are both situated on the left bank of the Mandovi. The river Mapusa is a tributary of the Mandovi.

Three large freshwater isles — Divar, Chorao and Vashee are present in the Mandovi near the town of Old Goa. Spanning across the Mandovi River near Panjim is the majestic Mandovi Bridge. The Mandovi Bridge links the towns of Panjim to Betim.

During the winter months, the peak tourist season, special dusk cruises on the Mandovi complete with serenading bands add to the charm of the river.